Objective To explore the value of expression level of serum heat shock protein 70(HSP70)and CC chemokine receptor 3(CCR3)for disease assessment in children with bacterial pneumonia(BP).Methods A total of 113 children with BP who were admitted to the Sinopharm Dongfeng General Hospital,Hubei University of Medicine from June 2022 to J une 2023 were recruited,they were assigned to the mild illness group(n=71)and the severe illness group(n=42)according to the condition.The gender,age,body mass index(BMI),and clinical data such as lung function index(respiratory rate[RR],tital volume[VT],the ratio of volume to peak expiratory flow to total expiratory volume[VPTEF/VE])were collected between groups.Enzyme-linked immunosorbent assay was used to detect serum levels of HSP70 and CCR3 of collecting 5mL of fasting venous blood in the morning.Receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of serum levels of HSP70 and CCR3 for disease assessment in BP children.Pearson analysis was used to investigate the relationship between serum levels of HSP70 and CCR3 with the severity of the condition.Results There was no statistically significant difference in general data such as gender,age,and BMI between the two groups(P＞0.05).The serum levels of HSP70,CCR3,and RR in the severe group were significantly higher than those of the mild group,while VT and VPTEF/VE were significantly lower(P＜0.05).The areas under curve(AUC)of the combination of serum HSP70 and CCR3 for BP children was 0.916,significantly higher than that single measured(Z=2.480,3.322,P＜0.05).The severity of the condition in BP children was significantly positively correlated with the expression levels of serum HSP70 and CCR3(r=0.826,0.778,P＜0.05).Conclusion The expression levels of serum HSP70 and CCR3 in BP children are significantly increased,which is closely related to the severity of the disease.It can be used as a clinical indicator for evaluating the severity of disease in BP children.
bacterial pneumoniaCC chemokine receptor 3heat shock protein 70illness assessment
NETL
NSTL
万方数据
