Ischemic stroke is one of the leading causes of morbidity and disability worldwide.It can be divided into two types of cerebral arterial insufficiency(especially the middle cerebral artery)and basilar artery insufficiency.The blocked blood flow results in insufficient supply of oxygen and nutrition to brain cells and thus causes ischemic injury.Neovascularization is an adaptive response to an ischemic state.Stimulated by the insufficient blood supply to local tissues,a series of growth factors and cytokines are released to promote the proliferation and migration of vascular endothelial cells to form new blood vessels.This process,called neovascularization,aims to improve the blood supply to the ischemic area and maintain the normal function of the tissue.Neovascularization plays an important role in ischemic stroke,in which the Survivin protein is thought to have a potential function to promote neovascularization.This article reviews the connection between Survivin and ischemic stroke,the mechanism of Survivin in regulating neovascularization,and the application of Survivin in the treatment of ischemic stroke based on the latest research at home and abroad.
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