Objective To observe the effect of nursing intervention under the guidance of 6S management mode on reducing the infection rate of arm infusion port.Methods A total of 101 breast cancer patients implanted with an arm infusion port from March 2019 to March 2020 were the study objects.Patients admitted from March 2019 to August 2019 were enrolled in the control group(n=42)and managed by routine nursing for arm infusion port,and those admitted from September 2019 to March 2020 were enrolled in the intervention group(n=59)and managed by nursing intervention under the guidance of 6S management mode.The infection rate of arm infusion port,catheter tip location,first-attempt success rate of needle puncture,specialty quality pass rate,intravenous therapy nursing quality,nursing safety,nursing skill level,cognition of 6S management,equipment management standard rate,port infusion time,patient satisfaction,and health education mastery rate were compared.Results Patients in the intervention group had significantly lower infection rate of arm infusion port,higher first-attempt success rate of needle puncture and better catheter tip location than those of control group(P<0.05).Specialty quality pass rate,intravenous therapy nursing quality,and nursing safety were significantly higher in the intervention group than those of control group(P<0.01).Nursing skill level,cognition of 6S management,and equipment management standard rate were significantly higher in the intervention group than those of control group(P<0.05).Port infusion time,patient satisfaction,and health education mastery rate were significantly superior in the intervention group than those of control group(P<0.01).Conclusion Nursing intervention under the guidance of 6S management mode can significantly reduce the infection rate of arm infusion port,ensure nursing safety,improve nursing quality and patient satisfaction.