Expression levels of survivin and VEGF-C in patients with papillary thyroid carcinoma and their synergistic effect on lymph node metastasis
Objective To investigate the expression levels of survivin and vascular endothelial growth factor-C(VEGF-C)in patients with papillary thyroid carcinoma(PTC)and their synergistic effect on lymph node metastasis(LNM).Methods This was a prospective study involving 86 patients with PTC in our hospital from January 2019 to December 2020 were enrolled as research subjects.The expression levels of survivin and VEGF-C were measured in all subjects at admission,and the pearson correlation coefficient was used to analyze the correlation between survivin and VEGF-C.After 1-year of followed-up,patients were divided into metastasis group and non-metastasis group according to whether or not LNM.Logistic regression equation was performed to analyze the effect of survivin and VEGF-C expression levels on LNM in PTC patients.The receiver operating characteristic(ROC)curve was drawn to assess its predictive performance.Results Of the 86 PTC patients who were followed up for 1 year,there were 29 with LNM(metastasis group),50 without LNM(non-metastasis group),and 7 patients with lost to follow-up.The expression levels of survivin and VEGF-C in the metastasis group were significantly higher than those of the non-metastasis group.Pearson correlation coefficient analysis showed that the expression levels of survivin and VEGF-C were positively correlated(r=0.418,P＜0.05).Logistic regression equation analysis verified that the high expression of both survivin(OR=1.952)and VEGF-C(OR=1.790)were risk factors for LNM in PTC patients.The ROC curve analysis showed that the areas under the curve(AUC)of survivin and VEGF-C was 0.878 and 0.776,respectively.Conclusion The expression levels of survivin and VEGF-C are positively correlated,and they play a synergistic role in promoting LNM in PTC patients.
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