Effect of preventive application of oxycodone at varying doses on the postoperative pain of patients undergoing thoracoscopic surgery
Objective To observe the effect of oxycodone at 0.1mg/kg versus 0.15mg/kg on the postoperative pain of patients undergoing thoracoscopic surgery.Methods A total of 80 patients undergoing thoracoscopic surgery from January 2022 to July 2022 were randomly allocated to the observation group(n=40)and the control group(n=40).Patients in both groups were given preventive analgesia 30min before the end of the surgery by intravenous administration of oxycodone at 0.1mg/kg(control group)and 0.15mg/kg(observation group).The Numerical Rating Scale(NRS)scores at 1,6,12 and 24h postoperatively,and the adverse events at 24 h postoperatively were recorded and compared between groups.Results his study included a total of 80 patients who were randomly divided into a control group and an observation group.There was no statistically significant difference in age,gender,and other general information between the two groups(P＞0.05);The difference in relevant biochemical indicators between the observation group and the control group at admission was not statistically significant(P＞0.05);The NRS scores at lh and 6h postoperatively were significantly lower in patients of the observation group than those of control group(P＜0.05),which,at 12h and 24h postoperatively were comparable between groups(P＞0.05).There were no significant differences in the incidence of adverse events and awaking time between groups(P＞0.05).Conclusion A preventive application of oxycodone at 0.15mg/kg effectively alleviates postoperative pain of patients undergoing thoracoscopic surgery without increasing the incidence of adverse events.
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