Objective To investigate the effect of oxitinib combined with whole brain radiotherapy on non-small cell lung cancer(NSCLC).Methods Totally 86 patients diagnosed with NSCLC and brain metastasis in our hospital from June 2019 to June 2020 were enrolled and randomly divided into experimental group(n=43)and control group(n=43).All patients were managed by conventional chemotherapy combined with whole brain radiotherapy,those in the experimental group were additionally given oxitinib.The short-term efficacy,serum tumor marker levels,adverse reactions and survival were included as comparisons.Results The effective rate of the experimental group was significantly higher than that of the control group(88.4％vs 62.8％,P＜0.05).The serum CD4+,CD8+and CD4+/CD8+ratio in experimental group were significantly higher than those of control group(P＜0.05).Meanwhile,the level of serum cytokeratin fragment antigen 21-1(CYFRA21-1)in the experimental group was significantly lower than that in the control group(P＜0.05).The log-rank test showed that the median time of disease-free survival in the experimental group was significantly longer than that of the control group(8 months vs 5 months,P＜0.05).Conclusion The combination of oxitinib and whole brain radiotherapy is a good treatment for patients with NSCLC and brain metastasis,which can prolong the disease-free survival time and improve the quality of life of patients.Therefore,it has a good clinical application value.
维普
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