Effects of multiple uses of propofol on the heart rate,mean arterial pressure and bispectral index during double lumen bronchial intubation in elderly patients under general anesthesia
Objective To investigate the effects of multiple uses of propofol on the heart rate(HR),mean arterial pressure(MAP)and bispectral index(BIS)during double lumen bronchial intubation in elderly patients under general anesthesia.Methods A total of 60 elderly patients who received general anesthesia in our hospital from June 2022 to June 2023 were randomly selected.According to the numerical table method,patients were randomly assigned into the observation group(n=30)and control group(n=30).A single administration of propofol was performed in the control group,and multiple uses of propofol were given to patients in the observation group.HR,MAP,BIS,operation time,recovery time,propofol dosage and incidence of adverse reactions between the two groups were compared.Results At T1,HR and MAP of the observation group were significantly lower than those of the control group(P＜0.05).HR and MAP at T1 in the control group were significantly higher than those at T0.At T0 and T2,there were no significant differences in HR and MAP between the two groups or compared with the same group at T0(P＞0.05).At T1 and T2,BIS in both groups was significantly lower than that at T0(P＜0.05).At T0,T1 and T2,there was no significant difference in BIS between groups(P＞0.05).The recovery time of observation group was significantly less than that of control group(P＜0.05).There were no significant differences in operation time and propofol dosage between groups(P＞0.05).One day after surgery,the Montreal Cognitive Assessment(MoCA)scores in both groups were significantly lower than those one day before surgery(P＜0.05).One day before and one day after surgery,there was no significant difference in the MoCA score between the observation group and the control group(P＞0.05).No significant difference was detected in the incidence of adverse reactions between groups(P＞0.05).Conclusion In the induction period of anesthesia,the hemodynamic fluctuation and anesthesia depth of the elderly patients under general anesthesia can be significantly improved by using propofol,and with good safety.
维普
万方数据
