Oral submucous fibrosis(OSF)is a chronic,latent disease classified as oral potentially malignant disorder,which is a global and regional public health problem.It is considered to be a multifactorial disease,and its inducements include chewing areca nut,micronutrient disorders genetic predisposition,etc.In this paper,various methods for the treatment of OSF in recent years at home and abroad are reviewed and summarized,covering drug therapy,surgical therapy,physical therapy,etc.The above methods are mainly to reduce the symptoms of this disease.The single effective method to treat OSF is still unreported.It is noteworthy that some researchers have proposed a new treatment-Stem cell therapy,while the number of observed cases is small,and its efficacy and safety need to be further studied.
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