Insulin like growth factor-1(IGF-1)is a peptide with a similar structure to insulin that participates in physiological processes like cell growth,differentiation,material metabolism,and wound repair.IGF-1 mainly forms complexes with insulin like growth factor binding protein-3(IGFBP-3)in the blood,and they regulate the biological activity and half-life of IGF-1.Diabetes retinopathy(DR)is a common microvascular complication of diabetes,which affects vision and even leads to blindness.A growing number of studies have suggested the involvement of IGF-1 in the occurrence and development of DR.This article reviewed the progress of IGF-1 in DR and its mechanism of action.
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