Objective To investigate the impact of implementing an extended infusion port management plan after chemotherapy in malignant tumor patients on catheter function and risk of complications.Methods A total of 105 malignant tumor patients implanted in the infusion port from January 2020 to January 2023 were included as the study subjects.They were randomly assigned 4-week group,8-week group and 12-week group according to the number table method,with 35 cases in each group.The infusion port management plan was performed every 4,8 and 12 weeks in the three groups,respectively.The cognitive level of infusion port maintenance knowledge,thrombosis risk assessment scores,incidence of adverse events,cost of catheter maintenance were compared among the three groups.Results After catheterization,the cognitive level of infusion tube maintenance knowledge in all three groups improved,but there was no significant difference among the three groups(P>0.05).There was no significant difference in the thrombosis risk assessment scores among the three groups(P>0.05).There was no significant difference in the incidence of adverse events among the three groups(P>0.05).There was a significant difference in nursing satisfaction scores among the three groups,with the highest score graded in the 12-week group,followed by the 8-week group and 4-week group(P<0.05).The cost of catheter maintenance in the 4-week group was significantly higher than that of the 8-week group,and it was significantly higher in the 8-week group than that of the 12-week group(P<0.05).Conclusion The infusion port management plan maintained every 4,8 and 12 weeks do not produce differences in thrombosis risk and complication risk.The management with an interval of 12 weeks has higher patient satisfaction and lower catheter maintenance costs.However,during the maintenance interval,it is necessary to strengthen the self-management at home and concern cognitive issues related to catheter maintenance.