Effect of remifentanil combined with dexmedetomidine on intraoperative controlled hypotension in patients aged more than 60 years undergoing total knee arthroplasty
Objective To study the effect of remifentanil combined with dexmedetomidine on intraoperative controlled hypotension in patients aged more than 60 years undergoing total knee arthroplasty(TKA).Methods This was a parallel,randomized study involving 104 patients aged more than 60 years who received TKA in Funan county people's hospital from March 2021 to February 2023,they were assigned into control group(n=52)and experimental group(n=52).All patients were managed by dexmedetomidine during operation,and those in experimental group were additionally given remifentanil.The systolic blood pressure(SBP)and diastolic blood pressure(DBP),and heart rate at different intraoperative time periods(before anesthesia,before and after intubation,10 min intraoperatively,30 min intraoperatively,3 min after discontinuation),the time to achieve the controlled hypotensive target,and the quality of anesthesia recovery between groups were compared.Results Before and after intubation,and at 10 min and 30 min intraoperatively,the experimental group had significantly lower SBP,DBP and heart rate,shorter the time to achieve the controlled hypotensive target,higher quality of anesthesia recovery than the control group(all P＜0.05).Conclusion The combination of remifentanil and dexmedetomidine can improve the effect of controlled hypotension and the quality of anesthesia recovery in patients aged more than 60 years undergoing TKA.
total knee arthroplastyaged more than 60 yearsremifentanildexmedetomidinecontrolled hypotension
万方数据
维普
