Progress of the Toll-like receptor family in hepatic ischemia-reperfusion injury
Hepatic ischemia-reperfusion injury(HIRI)is the main cause of impaired liver function after hepatobiliary surgery,shock and traumatization,which seriously affects the prognosis.Alleviating HIRI not only facilitates postoperative recovery,but also improves the survival rate.However,the mechanisms involved in HIRI are extremely complex.Effective preventive and curative measures for HIRI are currently lacked.It is important to perform an in-depth exploration of the pathophysiological mechanisms of HIRI.In recent years,Toll-like receptors(TLRs)have been validated to be involved in HIRI,which may play a beneficial role in attenuating HIRI.This review aims to elaborate the latest research progress of TLRs involved in HIRI,as well as to outline the emerging therapeutic strategies to improve HIRI through TLRs,so as to provide ideas and theoretical basis for clinical control of HIRI,drug development and management strategies.
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