Research progress on the correlation between CD4+T lymphocyte subsets and myocardial infarction
Myocardial infarction(MI)is one of the leading causes of death and disability worldwide,which seriously endangers the lives and health of people.A further exploration of the pathological mechanism of MI is conducive to the diagnosis,treatment and prognosis of acute MI(AMI).MI involves a complex pathological process.Criminal blood vessels often contain a large number of immune cells that can induce inflammation,among which type 1 helper T(Th1)cells in the CD4+T cell subgroup are the most common ones.In addition,the contents of Th2 cells,Th17 cells,regulatory T cells(Treg),Th9 cells,Th22 cells and follicular auxiliary T(Tfh)cells realso low.These CD4+T cells release a variety of cytokines through autocrine or paracrine mode and regulate the occurrence and development of atherosclerotic plaques by acting on inflammatory cells.Thus,it promotes the occurrence and development of MI and affects the prognosis of patients.This review summarized the research progress of CD4+T cell subsets in the occurrence and development of MI,post-infarction inflammatory response and adverse ventricular remodeling,with a view to further elucidate the pathological process of MI and provide new potential targets for prevention,treatment and improvement of prognosis of MI.
myocardial infarctionCD4+T lymphocyte subsetshelper T cellsregulatory T cells
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