Correlation between levels of TAT,TM,PIC,t-PAIC with prognosis of hornet sting injuries
Objective To explore the correlation between plasminogen activator inhibitor-complex(PIC),tissue-type plasminogen activator inhibitor complex(t-PAIC),thrombin-antithrombin complex(TAT),thrombomodulin(TM),with the prognosis of hornet sting.Methods A total of 78 patients with hornet sting admitted to the Department of Emergency,the First People's Hospital of Changde City from April 2019 to March 2023 were enrolled,and they were divided into the good prognosis group and poor prognosis group based on their prognosis.The baseline data,as well as the levels of PIC,t-PAIC,TAT,TM,D-dimer(DD),fibrin degradation products(FDP),prothrombin time(PT),and activated partial thromboplastin time(APTT)were compared between the two groups.Receiver operating characteristic(ROC)curve analysis was conducted to evaluate the predictive efficacy of the aforementioned factors on the prognosis of hornet sting.Results The proportion of intravascular hemolysis,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,Sequential Organ Failure Assessment(SOFA)score,number of sting,and lactate level were significantly higher in the poor prognosis group than in the good prognosis group(P＜0.05).The plasma levels of TAT,TM,PIC,and t-PAIC were significantly higher in the poor prognosis group than in the good prognosis group(P＜0.05).The levels of FDP,DD,APTT,and PT were significantly higher in the poor prognosis group compared to the good prognosis group(P＜0.05).PIC,t-PAIC,TAT,and TM were all risk factors for poor prognosis of hornet sting(P＜0.05).ROC curve analysis showed that the sensitivity of TAT,TM,PIC,t-PAIC,and their combination in predicting poor prognosis caused by hornet sting was 67.90％,75.00％,53.60％,64.30％,and 89.00％respectively,and the corresponding area under the curve(AUC)was 0.799,0.767,0.690,0.678,and 0.919,respectively.Conclusion The levels of PIC,t-PAIC,TAT,and TM were abnormal in patients with poor prognosis,and their combination had a high early predictive value for poor prognosis caused by hornet sting.
hornet stingactivated partial thromboplastin timeprothrombin time
万方数据
