Effect of different dosages of propofol used in anesthesia maintenance on the cognitive function after double-lumen bronchial intubation
Objective To explore the effect of different dosages of propofol used in anesthesia maintenance on the cognitive function after double-lumen bronchial intubation.Methods Ninety-three patients,with 18-60 years of age,body mass index(BMI)of 18-24kg/m2,and the American Society of Anesthesiologists(ASA)physical status classification ofⅠ-Ⅱ,who were treated with double-lumen bronchial intubation in our hospital between January 2022 and June 2023 were selected as the study subjects.They were randomly assigned into group A(n=33),group B(n=33)and group C(n=34),with the same regimen of anesthesia induction.For maintaining anesthesia,pumping infusion of propofol at 1.0mg·kg-1·h-1,2.0mg·kg-1·h-1 and 3.0mg·kg-1·h-1 at a constant rate was performed in three groups,respectively.Remifentanil dose was adjusted to maintain the mean arterial pressure(MAP)decreased by 5％of baseline.Changes in hemodynamic indicators(MAP,heart rate[HR],and oxygen saturation[SpO2],respiratory indicators(peak airway pressure[Ppeak],mean airway pressure[Pmean],tidal volume of expiration[TV],and pulmonary dynamic compliance[CLdyn]),cognitive function(the Mini-Mental State Examination[MMSE]score)and adverse events were compared among the three groups.Results Patients in tll three groups achieved a MAP decreased by 0-10％of baseline during anesthesia maintenance,with the maintenance effect of grade Ⅰ.There were no significant differences in the MAP and HR at T0-T3 among the three groups(P＞0.05).SpO2 at T0 was comparable among the three groups,but significantly higher in group C than group A and B at T1-T3(P＜0.05).There were no significant differences in Ppeak,Pmean,TV and CLdyn at TO among the three groups(P＞0.05).At T1-T3,Ppeak and Pmean of group B and C were significantly lower than those of group A(P＜0.05),but comparable between group B and C(P＞0.05).TV and CLdyn in group C were significantly higher than those of group A and B(P＜0.05),but comparable between group A and B(P＞0.05).No significant difference was detected in the incidence of adverse events among the three groups(P＞0.05).From preoperative to 72h postoperatively,the MMSE scores in the three groups first declined and then increased,without a significant difference at the four time points(P＞0.05).Conclusion The maintenance dose of propofol at 3.0mg·kg-1·h-1 can maintain better tidal volume and lung compliance,which is more ideal for maintaining hemodynamic stability.
double-lumen bronchial intubationpropofolmaintenance dosecognitive function
万方数据
维普
