Research progress on the role of the STIL gene in the occurrence and development of malignant tumors
SCL/TAL1 interrupting locus(STIL)is a cytosolic protein involved in the regulation of mitotic spindle checkpoints,mitosis and malignant transformation of cells by mediating centrosome replication.It is overexpressed in tumors,and closely related to the occurrence and development of gastric cancer,liver cancer,pancreatic cancer,ovarian cancer,breast cancer,prostate adenocarcinoma and osteosarcoma.STIL influences the occurrence and development of malignant tumors via various mechanisms.Knockout of STIL can inhibit tumor cell proliferation,invasion and migration,indicating that STIL can be regarded as a potential therapeutic target for tumor therapy.Therefore,in-depth study of the expression,biological function and regulatory mechanism of the STIL gene in malignant tumors can provide new ideas for early diagnosis and targeted therapy of patients with malignant tumors.
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