Effects of deoxyepinephrine and noradrenaline on the application of intracranial and extracranial revascularization for moyamoya disease and their influences on hemodynamic stability,cerebral perfusion and cerebral infarction
Objective To investigate the effects of deoxyepinephrine and noradrenaline on the hemodynamic stability,cerebral perfusion and cerebral infarction in revascularization of moyamoya disease(MMD).Methods In this study,98 MMD patients admitted from February 2021 to January 2023 were randomly selected and divided into the control group and observation group,with 49 cases per group.In the control group,assisted anesthesia by preoperative intravenous deadrenaline and surgery were performed.Patients in the observation group underwent norepinephrine-assisted anesthesia and surgery.Hemodynamic data,oxidative metabolism index and indicators of central nervous dysfunction were observed in both groups.Results The mean arterial pressure and central venous pressure were comparable between groups(P＞0.05).The heart rate level was significantly better in the observation group than the control group(P＜0.05).The overall cerebral perfusion performance,including jugular venous oxygen saturation(SjvO2),the content of arterial venous difference(DajvO2),and VADL,were similar between groups(P＞0.05).The incidence of adverse events such as bradycardia in the observation group was significantly lower than that of the control group(P＜0.05).Conclusion The application of deoxyepinephrine and noradrenaline in MMD can effectively maintain the stable hemodynamics,improve the intraoperative cerebral perfusion level,and reduce the incidence of postoperative cerebral infarction.
维普
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