Objective To observe the clinical effect of gastrointestinal combined with systemic nutritional support on patients with esophageal cancer undergoing immunotherapy.Methods A total of 130 patients with esophageal cancer who received immunotherapy in our hospital were selected as the objects of this study from January 2021 to December 2021.All patients were randomly divided into two groups by numerical table method:observation group(65 cases)and control group(65 cases).The control group implemented routine management,while the observation group constructed gastrointestinal combined with systemic nutrition support intervention based on routine management.The incidence of gastrointestinal adverse events,nutritional status,quality of life and satisfaction were compared between groups.Results Significantly lower incidences of diarrhea and the severity of dehydration,shorter duration of diarrhea and lower average frequency of defecation were detected in the observation group than the control group(all P＜0.05).Before intervention,there were no significant differences in the body mass index(BMI),the Patient-Generated Subjective Global Assessment(PG-SGA)score,nutritional indexes(serum albumin,hemoglobin and transferrin)and quality of life score between the two groups.After intervention,significantly decreased BMI and increased PG-SGA score,nutritional indexes and quality of life score were detected in both groups,which were significantly pronounced in the observation group(all P＜0.05).The satisfaction score in the observation group was significantly higher than the control group(P＜0.05).Conclusion The construction and application of gastrointestinal combined with systemic nutrition support intervention during the immunotherapy of esophageal cancer can alleviate the diarrhea symptoms,improve the nutritional level,reduce the incidence of fatigue,and enhance the quality of life and satisfaction.
esophageal cancerimmunotherapygastrointestinaladverse reactionsnutrition supportquality of life
万方数据
维普
