Objective To investigate the effects of early enteral nutrition support on immune function and serum biochemical indexes in patients with esophagogastric variceal bleeding(EGVB)and cirrhosis for ligation.Methods A total of 93 EGVB patients who received endoscopic ligation from July 2022 to June 2023 were selected as the study subjects,and they were randomly divided into early nutrition group(47 cases)and conventional nutrition group(46 cases)by random number table method.The early nutrition group was given enteral nutrition support at 6h after surgery,and the conventional nutrition group was given enteral nutrition support at 24h after surgery.The cellular immune function,nutritional index,liver function and complications were compared between the two groups.Results Two weeks after operation,CD3+,CD4+and CD4+/CD8+in early nutrition group were significantly higher than those in conventional nutrition group,and CD8+was significantly lower(P＜0.05).Serum prealbumin(PA),transferrin(TRF)and retinol-binding protein(RBP)were significantly higher than those in conventional nutrition group(P＜0.05).Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)were significantly lower than those in conventional nutrition group(P＜0.05).After 6 weeks of follow-up,the incidence of recurrent varicose veins(6.38％),recurrent bleeding(2.13％)and infection(4.26％)in the early nutrition group was significantly lower than that in the conventional nutrition group(21.74％,13.04％,and 17.39％,respectively)(X2=4.559,3.980,and 4.180,respectively;P＜0.05).Conclusion Early enteral nutrition support can improve cellular immune function,promote nutritional status and liver function recovery in EGVB patients treated with surgical ligation,and prevent postoperative complications such as rebleeding.
esophagogastric variceal hemorrhageligationearly enteral nutritionimmune functionnutritional index
维普
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