Objective To investigate the effect of ipratropium bromide combined with budesonide on children with acute asthmatic bronchitis.Methods A total of 82 children with acute asthmatic bronchitis admitted to the First People's Hospital of Mengcheng County Bozhou City,Anhui Province from January 2020 to January 2023 were selected as the research objects.They were divided into control group and study group by random number table method,with 41 cases in each group.The control group was treated with budesonide aerosol inhalation,and the study group was treated with ipratropium bromide on the basis of the control group.The clinical efficacy,improvement of clinical symptoms,immune function and adverse reactions of the children were evaluated.Results The clinical effect of the study group was significantly higher than that of the control group(P＜0.05).The disappearance time of cough,asthma,wheezing and moist rales in the study group was significantly shorter than that in the control group(P＜0.05).There was no significant difference in the levels of immune function indexes between groups before treatment(P＞0.05).After treatment,the levels of CD3+,CD4+,CD4+/CD8+in the study group were significantly higher than those of the control group(P＜0.05),while the level of CD8+was significantly lower than the control group(P＜0.05).Although the incidence of adverse events was lower in the study group than that of the control group,there was no significant difference between the two groups(P＞0.05).Conclusion Ipratropium bromide combined with budesonide in the treatment of children with acute asthmatic bronchitis has an ideal clinical efficacy and high safety,which can effectively relieve clinical symptoms and signs,improve immune function and promote quality of life.The combination therapy has a high clinical application value.
ipratropium bromidebudesonidechildren with acute asthmatic bronchitiseffectquality of life
维普
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