Objective To explore the effect of comprehensive rehabilitation intervention on disease control,blood gas index and pulmonary function in patients with severe pneumonia.Methods A total of 86 patients with severe pneumonia treated in our hospital from May 2022 to May 2023 were randomly assigned into observation group(n=43)and control group(n=43).All patients were managed by routine intervention,and those in observation group were additionally given comprehensive rehabilitation intervention.The incidence of adverse events,disease control,blood gas index,pulmonary function were included as comparators.Results The incidence of adverse events in the observation group was significantly lower than that in the control group(4.65%vs 3.26%,P<0.05).After intervention,the clinical pulmonary infection score(CPIS),Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE-Ⅱ)score were significantly lower in the observation group than in the control group(P<0.05).Significantly higher peripheral arterial haemoglobin oxygen saturation(SPaO2)and partial pressure of arterial oxygen(PaO2),and lower partial pressure of carbon dioxide(PaCO2)were found in observation group than those of control group(all P<0.05).The percentage of forced expiratory volume in the first second after expiration for predicted values(FEV1%pre),forced vital capacity(FVC),peak expiratory flow(PEF)increased notably in the observation group compared to the control group(P<0.05).Conclusion Comprehensive rehabilitation intervention can reduce the incidence of adverse events,effectively control the disease,and further improve blood gas index and pulmonary function in patients with severe pneumonia.