Objective To investigate the formation of medium length venous catheter-related thrombosis(CRT)in 117 patients with malignant tumors and to analyze its influencing factors.Methods A retrospective study was conducted on the medical records of 117 malignant tumor patients who underwent medium length venous catheterization in Beijing Luhe Hospital,Capital Medical University from January 2021 to June 2023.According to the incidence of CRT,17 patients(14.53%)with CRT were classified as the occurrence group,while the other 100 patients(85.47%)were classified as the non-occurrence group.The baseline data and laboratory data of the two groups were compared,and the factors affecting the formation of CRT after medium-length venous catheterization in patients with malignant tumors were analyzed by univariate and multivariate analysis.Results The proportion of clinical stages Ⅲ-Ⅳ in the occurrence group was significantly higher than that in the non-occurrence group(P<0.05).The number of combined underlying diseases,catheterization time,and D-dimer(DD)levels were significantly higher in the occurrence group than those in the non-occurrence group(P<0.05).Logistic regression analysis showed that high clinical staging,multiple comorbidities,long catheterization time,and high DD levels were risk factors for CRT after medium length venous catheterization in 117 malignant tumor patients(OR>1,P<0.05).Conclusion Among 117 malignant tumor patients who received medium length venous catheterization,17(14.53%)developed CRT.High clinical staging,multiple comorbidities,large number of underlying diseases,long catheterization time and high DD level were risk factors for CRT.The nomogram created based on the above risk factors can well predict the risk of CRT in patients with malignant tumors with medium length venous catheterization.