首页|NLR、PLR、PCT对重症脓毒症患者感染性休克的预测价值

NLR、PLR、PCT对重症脓毒症患者感染性休克的预测价值

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目的 研究中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和血清降钙素原(PCT)在重症脓毒症患者感染性休克预测中的价值.方法 选取2019年12月至2022年12月接收的96例重症脓毒症患者为研究对象.依照患者是否出现脓毒症感染性休克进行分组,将58例重症脓毒症患者设为对照组,38例重症脓毒症感染性休克患者设为研究组,分析NLR、PLR、PCT对重症脓毒症患者感染性休克的预测价值.结果 2组患者性别、年龄、氧合指数、乳酸、心率等一般资料比较差异无统计学意义(P>0.05),研究组SOFA评分与APACHE Ⅱ评分高于对照组(P<0.05),研究组患者NLR、PCT、PLR水平高于对照组(P<0.05),将2组间比较具有统计学意义的SOFA评分、APACHE Ⅱ评分、NLR、PCT、PLR指标应用多变量Logistic回归分析后,结果揭示:NLR、PCT和PLR被确认为影响严重脓毒症患者发展为感染性休克的独立风险因素(P<0.05).NLR、PCT、PLR单一指标中PCT对预测脓毒症患者病情严重程度的价值较高.NLR、PCT、PLR联合的灵敏度与特异性最高.结论 NLR、PLR和PCT联合检测,对重症脓毒症患者感染性休克的预测具有很高参考价值.
Prediction value of NLR,PLR and PCT for infectious shock in patients with severe sepsis
Objective To study the prediction value of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and procalcitonin(PCT)for infectious shock in patients with severe sepsis.Methods Ninety-six patients with severe sepsis admitted to our hospital between December 2019 and December 2022 were enrolled as research subjects.The patients were grouped into the control group(n=58)and the study group(n=38)based on the presence or absence of infectious shock.The predictive value of NLR,PLR,and PCT for infectious shock in patients with severe sepsis was analyzed.Results There was no difference in baseline data such as gender,age,oxygenation index,lactate and heart rate between the two groups(P>0.05).Patients in the study group had significantly higher scores of Sequential Organ Failure Assessment(SOFA)and the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ),and the levels of NLR,PCT and PLR relative to those in the control group(all P<0.05).Logistic regression analysis revealed that NLR,PCT,and PLR were independent risk factors affecting the development of infectious shock in patients with severe sepsis(P<0.05);among which,the PCT single index had a higher value in predicting the severity of sepsis patients;the combination of NLR,PCT,PLR had the highest sensitivity and specificity.Conclusion The combination of NLR,PLR and PCT has a high reference value for the prediction of infectious shock in patients with severe sepsis.

neutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratioserum procalcitoninsevere sepsisinfectious shockprediction

董运辉、顾慧、王红蕊、李建如

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101100 首都医科大学附属北京友谊医院感染内科

中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 血清降钙素原 重症脓毒症 感染性休克 预测

2024

河北医药
河北省医学情报研究所

河北医药

CSTPCD
影响因子:1.075
ISSN:1002-7386
年,卷(期):2024.46(24)