Research progress of Wang-bi preparations in the treatment of rheumatoid arthritis
Rheumatoid arthritis(RA)is an autoimmune disease of unknown etiology,with a progressive condition,high incidence and high disability rate.It easily causes huge physical,mental pain and economic burden to patients.The pathogenesis of RA is still unclear.Although Western medicine can control the progression of RA,it causes adverse events and increases the risk of secondary infections and gastrointestinal diseases.Wang-bi preparations include Wang-bi capsules and Wang-bi tablets,which is a Chinese patent medicine made by Jiao Shu-de.It is functional of tonifying kidney and strengthening bone,eliminating wind and removing dampness,and activating meridians to stop pain,which has been widely used in clinic.In recent years,modern clinical and pharmacological studies have shown that quercetin,luteolin,kaempferol and stigmasterol are the active components in Wang-bi preparations,which can effectively treat RA with the properties of anti-inflammatory and analgesic activities,immune regulation,and inhibition of bone destruction,presenting a wide application prospect.This study discussed the etiology and pathogenesis of RA and reviewed the research progress of Wang-bi preparations in the treatment of RA from the aspects of chemical composition,clinical research and basic research.We also clarified its effectiveness and safety.Our article provided a certain theoretical basis for its application prospects,and a deeper thinking for the widespread application of traditional Chinese medicine in the clinic of RA.
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