仿生氟掺杂羟基磷灰石涂层的结构分析和成骨分化性能

Structure Analysis and Osteogenic Differentiation Capacity of Biomimetic Fluoridated Hydroxyapatite Coating

赵秀英 ¹张璐 ¹鲍小刚 ²刘微 ³杨越冬 ¹申偲伯¹

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作者信息

1. 河北科技师范学院化学工程学院河北省天然产物活性成分与功能重点实验室,河北秦皇岛,066600
2. 海军军医大学第二附属医院骨科脊柱外科
3. 清华大学深圳国际研究生院
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摘要

为了探究镁合金表面仿生氟掺杂羟基磷灰石(FHA)涂层的成骨性能,应用微波液相法在AZ31B镁合金表面分别制备了仿生FHA涂层和羟基磷灰石(HA)涂层,使用XRD,SEM,EDS,TEM,光学轮廓仪分析了涂层的拓扑结构和化学组成,并以小鼠骨髓间充质干细胞为培养对象,应用CCK-8法和RT-PCR法测试了涂层的细胞活力和成骨分化性能.结果表明,FHA涂层由六棱柱型纳米针自下而上构建,形成一种可模仿骨吸收面的仿生微/纳拓扑结构;FHA涂层能够抑制镁合金的早期降解进而维持正常细胞活力,并增强成骨分化性能.

Abstract

Biomimetic FHA coating and hydroxyapatite coating were prepared on AZ31B magnesium alloys via a microwave aqueous route to study the osteogenic differentiation capacity of biomimetic fluoridated hydroxyap-atite(FHA)coating on magnesium alloy.Biomimetic FHA coating and hydroxyapatite coating were prepared on AZ31B magnesium alloys via a microwave aqueous route to study the osteogenic differentiation capacity of biomimetic fluoridated hydroxyapatite(FHA)coating on magnesium alloy.The results indicated that FHA coating was constructed by hexagonal prism-type nanoneedles in a bottom-up way,resulting in a kind of biomi-metic micro/nano-topography for mimicking bone absorption surface.FHA coating could inhibit magnesium al-loy early-stage degradationand enhance osteogenic differentiation capacity.

关键词

FHA涂层/拓扑结构/化学组成/成骨分化性能

Key words

Fluoridated hydroxyapatite coating/topography/chemical composition/osteogenic differentiation capacity

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基金项目

国家自然科学基金(51802221)

河北省"三三三人才工程"项目(C20221031)

省属高校基本科研业务费专项(2020JK015)

出版年

2024

河北科技师范学院学报

河北科技师范学院

河北科技师范学院学报

影响因子：0.414

ISSN：1672-7983

参考文献量14

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