Objective:To investigate the protective effects of Qingwen Baidu Yin(QBY)on acute lung injury(ALI)induced by endotoxin in mice.Methods:A total of 72 kunming mice were randomly divided into normal group,model group,dexamethasone group,and high,medium,and low dose groups of QBY.An ALI model was established by intraperitoneal injection of lipopolysaccha-ride.On the 3rd and 7th days of treatment,6 mice from each group were sacrificed.Blood samples were collected,and lung tissues were isolated from the mice.The wet-to-dry ratio of lung tissues was measured.ELISA and PCR were used to detect the expression of relevant factors in serum and lung tissues;and pathological changes in the lung tissues of the mice were observed.Results:Compared with the model group,the pathological damage of lung tissues in the various dose groups of QBY was reduced,with a decrease in the wet-to-dry ratio(W/D)of lung tissues;The expression levels of interleukin-1(IL-1),tumor necrosis factor-alpha(TNF-α)in ser-um,and Toll-like receptor 4(TLR4),myeloid differentiation factor 88(MyD88),nuclear factor-kappa B(NF-κB),TLR4mRNA,and MyD88mRNA in lung tissues were decreased in the various dose groups,showing a dose-dependent effect among different dose groups(P＜0.05).Conclusion:QBY has a protective effect on acute lung injury induced by LPS in mice.
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