Treatment of Elderly Patients with Chronic Slow Transit Constipation of Liver-stagnation Kidney-deficiency Type with Modified Jiechangshu Combined with Clostridium Butyricum And Enterococcus Faecium Triple Viable Capsules
Objective:To investigate the clinical efficacy of the modified Jiechangshu formula combined with Clostridium Butyri-cum and Enterococcus Faecium Triple Viable Capsules in treating elderly patients with slow transit constipation(STC)of liver-stagna-tion kidney-deficiency type.Methods:A total of 100 elderly patients with STC of liver-stagnation kidney-deficiency type who visited Hebei Provincial Hospital of Traditional Chinese Medicine from December 2021 to June 2023 were selected and randomly divided into two groups,with 50 patients in each group.The observation group received a combination therapy of Clostridium Butyricum and Entero-coccus Faecium Triple Viable Capsules and modified Jiechangshu formula,while the control group received only Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules.Both groups underwent a 2-month treatment period.The Chinese medicine syndrome scores for constipation,results of colonic transit test,levels of intestinal neurotransmitter(5-HT),gut microbiota levels,and recur-rence rates were compared between the two groups before and after treatment.Results:The effective rate in the observation group after treatment was 96%,while that in the control group was 76%.After treatment,the Chinese medicine syndrome scores and the number of residual markers in the colonic transit test were lower in the observation group compared to the control group(P＜0.05);The serum level of 5-HT increased(P＜0.05);Among the gut microbiota levels,the numbers of lactobacillus and bifidobacterium increased,while the number of enterobacteria decreased(P＜0.05).Conclusion:The combination therapy of modified Jiechangshu formula and Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules is more effective than probiotics alone in treating elderly pa-tients with STC of liver stagnation and kidney deficiency type.
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