Objective:To investigate the impact of Dahuang Xiezhuo Decoction on high-risk patients with Idiopathic Membranous Nephropathy(IMN)and their immune indicators.Methods:Ninety high-risk IMN patients with the syndrome of combined turbidity and blood stasis were randomly divided into an observation group and a control group,with 45 patients in each group(one case dropped out in each group).The control group received basic symptomatic treatment plus oral prednisone acetate tablets and tacrolimus cap-sules.The observation group received Dahuang Xiezhuo Decoction orally on the basis of the control group's treatment.After 12 weeks of treatment for both groups,comparisons were made in terms of efficacy,traditional Chinese medicine(TCM)syndrome scores,serum B-cell activating factor(BAFF),urinary membrane attack complex C5b-9(MAC C5b-9,hereinafter referred to as C5b-9),urinary immu-noglobulin G4(IgG4),serum creatinine(Scr),24-hour urine total protein(24 hUTP),serum albumin(Alb),and the occurrence of adverse reactions.Results:After treatment,the clinical effective rate in the observation group was 88.64%,higher than the 70.45%in the control group(P＜0.05).The TCM syndrome scores,serum BAFF,urinary C5b-9,urinary IgG4,Scr,and 24 hUTP all decreased in both groups after treatment(P＜0.05),with the observation group showing better improvement than the control group(P＜0.05).The serum albumin(Alb)levels increased in both groups(P＜0.05),with the observation group showing superior improvement(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Dahuang Xiezhuo Decoction can improve the clinical symptoms of high-risk IMN patients,reduce the levels of serum BAFF,urinary C5b-9,and urinary IgG4,improve the immune imbalance state,protect renal function,and delay the pro-gression of kidney disease.
维普
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