Relationship Between Cerebral Blood Flow,Serum NT-3,BDNF and Functional Recovery in Patients with Acute Cerebral Infarction and Hemiplegia after Intervention
Objective To explore the relationship between cerebral blood flow,serum neurotrophic factor-3(NT-3),brain-derived neurotrophic factor(BDNF)and functional recovery in patients with acute cerebral infarction(ACI)and hemiplegia after intervention.Methods A total of 60 patients with ACI admitted to the hospital.After admission,all underwent routine treatments(anti-coagulation,anti-platelet,lipid regulation,removal of oxygen free radicals,promoting circulation and removing stasis)and comprehensive rehabilitation therapy.After 4 weeks of continuous intervention,cerebral blood flow[anterior cerebral artery(ACA),middle cerebral artery(MCA)],levels of serum NT-3 and BDNF,and functional recovery[National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer Assessment Scale(FMA)]were compared before and after treatment.Results After treatment,cerebral blood flow of ACA and MCA was increased(P<0.05).After treatment,level of serum NT-3 was decreased,while BDNF level was increased(P<0.05).After treatment,NIHSS score was decreased,while FMA score was increased(P<0.05).ACA,MCA and BDNF were negatively correlated with NIHSS score,while positively correlated with FMA score(P<0.05).NT-3 was positively correlated with NIHSS score,while negatively correlated with FMA score(P<0.05).Conclusion The cerebral blood flow,levels of serum NT-3 and BDNF significantly improve in patients with acute cerebral infarction and hemiplegia after intervention,which can better reflect the recovery level of limb function and motor function.
Acute cerebral infarction and hemiplegiaCerebral blood flowSerum brain-derived neurotrophic factorSerum neurotrophic factor-3Limb motor functionCognitive function
万方数据
维普
