摘要
目的 探讨急性脑梗死偏瘫患者干预后脑血流量和血清神经营养因子-3(NT-3)、脑源性神经营养因子(BDNF)水平与功能恢复的关系.方法 选取ACI患者 60 例,入院后均行常规治疗(抗凝、抗血小板、调脂、清除氧自由基和活血化瘀)和综合康复治疗,持续干预 4 周.比较患者治疗前、后脑血流量[大脑前动脉(ACA)、大脑中动脉(MCA)]、血清NT-3、BDNF水平和功能恢复[神经功能评价量表(NIHSS)、Fugl-Meyer运动功能量表(FMA)]水平.结果 治疗后急性脑梗死偏瘫患者ACA水平和MCA水平均高于治疗前(P<0.05).治疗后急性脑梗死偏瘫患者血清NT-3 水平低于治疗前,BDNF水平高于治疗前(P<0.05).治疗后急性脑梗死偏瘫患者NIHSS评分低于治疗前,FMA评分高于治疗前(P<0.05).ACA、MCA、BDNF与NIHSS评分呈负相关,与FMA评分呈正相关(P<0.05).NT-3 与NIHSS评分呈正相关,与FMA评分呈负相关(P<0.05).结论 急性脑梗死偏瘫患者干预后脑血流量和血清NT-3、BDNF水平有明显改善,可以较好反映患者肢体功能与运动功能的恢复水平.
Abstract
Objective To explore the relationship between cerebral blood flow,serum neurotrophic factor-3(NT-3),brain-derived neurotrophic factor(BDNF)and functional recovery in patients with acute cerebral infarction(ACI)and hemiplegia after intervention.Methods A total of 60 patients with ACI admitted to the hospital.After admission,all underwent routine treatments(anti-coagulation,anti-platelet,lipid regulation,removal of oxygen free radicals,promoting circulation and removing stasis)and comprehensive rehabilitation therapy.After 4 weeks of continuous intervention,cerebral blood flow[anterior cerebral artery(ACA),middle cerebral artery(MCA)],levels of serum NT-3 and BDNF,and functional recovery[National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer Assessment Scale(FMA)]were compared before and after treatment.Results After treatment,cerebral blood flow of ACA and MCA was increased(P<0.05).After treatment,level of serum NT-3 was decreased,while BDNF level was increased(P<0.05).After treatment,NIHSS score was decreased,while FMA score was increased(P<0.05).ACA,MCA and BDNF were negatively correlated with NIHSS score,while positively correlated with FMA score(P<0.05).NT-3 was positively correlated with NIHSS score,while negatively correlated with FMA score(P<0.05).Conclusion The cerebral blood flow,levels of serum NT-3 and BDNF significantly improve in patients with acute cerebral infarction and hemiplegia after intervention,which can better reflect the recovery level of limb function and motor function.
维普
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