Objective To analyze the clinical value of atorvastatin calcium combined with fenofibrate in the treatment of coronary atherosclerotic heart disease(CHD).Methods A total of 82 cases of CHD patient were selected and divided into a combination group(n=41)and a single group(n=41)by random number table method.The single group was treated with ator-vastatin calcium,and the combined group was treated with fenofibrate on the basis of a single group.The therapeutic effect,blood lipid levels[total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),triglyceride(TG)],carotid intimax-media thickness(IMT),vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1)],cardiac function[left ventricular end-systolic diameter(LVESD),and left ventricular ejection fraction(LVEF)]were compared between the two groups Number and the incidence of adverse reactions.Results The total effective rate of the combination group95.12%(39/41)was higher than that of the single group 80.49%(33/41)(P<0.05).After treatment,the TC and TG levels in the combination group were lower than those in the single group,and the HDL-C level was higher than those in the single group(P<0.05).After treatment,the level of carotid IMT in the combination group was lower than that in the single group(P<0.05).After treatment,the ET-1 lev-el in the combination group was lower than that in the single group,and the NO level was higher than that in the single group(P<0.05).After treatment,the LVEF level in the combination group was higher than that in the single group,and the LVESD level was lower than that in the single group(P<0.05).There was no significant difference in adverse reactions be-tween the two groups(P>0.05).Conclusion Fenofibrate combined with atorvastatin calcium in the treatment of CHD patients can improve the efficacy,reduce the blood lipid levels and carotid IMT thickness,and improve the vascular endothelial func-tion and cardiac function,which is safe and reliable.
关键词
阿托伐他汀钙/非诺贝特/冠心病/心功能
Key words
Atorvastatin calcium/Fenofibrate/Coronary atherosclerotic heart disease/Cardiac function
维普
万方数据