Effects of Low-dose Donepezil Hydrochloride Combined with Memantine Hydrochloride on Cognitive Function in Patients with Alzheimer's Disease
Objective To analyze the effects of donepezil hydrochloride combined with memantine hydrochloride on cog-nitive function in patients with Alzheimer's disease(AD).Methods 86 cases of patients with AD were selected,and all of them were randomly divided into an experimental group and a conventional group,with 43 patients in each group.The con-ventional group was given low-dose donepezil hydrochloride,and the experimental group was combined with memantine hy-drochloride on the basis of the conventional group.The curative effect,the Alzheimer's disease behavioralpathology scale(BE-HAVE-AD)score,the Alzheimer's Disease Assessment Scale(ADAS-cog),Mini Mental State Assessment Scale(MMSE),the in-flammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]levels and the occurrence rate of adverse reactionsof the two groups were compared.Results The total effective rate 93.02%(40/43)of the experimental group washigher than 72.09%(31/43)of the conventional group(P<0.05);After treatment,the BEHAVE-AD score of the ex-perimental group was lower than that of the conventional group(P<0.05);After treatment,the ADAS-cog score of the experi-mental group was lower than that of the conventional group,while the MMSE score was higher than that of the conventional group(P<0.05);After treatment,the levels of IL-6,TNF-α and CRP in the experimental groupwereall respectivelylower than thosein the conventional group(P<0.05);The occurrence rate of adverse reactions of the experimental group was 6.98%(3/43),which was not significantly different from that of the conventional group11.63%(5/43)(P>0.05).Conclusion The combi-nation of donepezil hydrochloride and memantine hydrochloride for AD patientshas a significant effect,which can improve the clinical symptoms,cognitive function and mental state,alleviate the inflammatory reactions,and has the safety.
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