Objective To investigate the effects of paroxetine combined with Mirtazapine on cognitive function and Hamilton Depression Scale(HAMD)score in patients with poststroke depression(PSD).Methods This was a prospective study.113 patients with poststroke depression were enrolled in this study.They were divided into observation group(n=57 cases)and control group(n=56 cases)by random number table.The control group received paroxetine treatment,and the observation group received paroxetine combined with mirtazapine treatment.Cognitive function[as assessed by Wisconsin card Sorting Test(WC-ST)],HAMD score and adverse effects were compared between the two groups.Results After treatment,WCST scores of both groups were improved,and scores of observation group were better than control group(P<0.05).After treatment,HAMD scores in both groups were decreased,and the observation group was lower than the control group(P<0.05).The adverse reactions of the two groups were compared(P>0.05).Conclusion Paroxetine combined with mirtazapine can effectively improve cognitive function and depression in patients with PSD.
关键词
卒中抑郁/帕罗西汀/米氮平/认知功能/抑郁程度
Key words
stroke depression/Paroxetine/Mirtazapine/Cognitive function/Degree of depression
维普
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