Effects of Paroxetine Combined with Mirtazapine on Cognitive Function and HAMD Score in Patients with Poststroke Depression
Objective To investigate the effects of paroxetine combined with Mirtazapine on cognitive function and Hamilton Depression Scale(HAMD)score in patients with poststroke depression(PSD).Methods This was a prospective study.113 patients with poststroke depression were enrolled in this study.They were divided into observation group(n=57 cases)and control group(n=56 cases)by random number table.The control group received paroxetine treatment,and the observation group received paroxetine combined with mirtazapine treatment.Cognitive function[as assessed by Wisconsin card Sorting Test(WC-ST)],HAMD score and adverse effects were compared between the two groups.Results After treatment,WCST scores of both groups were improved,and scores of observation group were better than control group(P<0.05).After treatment,HAMD scores in both groups were decreased,and the observation group was lower than the control group(P<0.05).The adverse reactions of the two groups were compared(P>0.05).Conclusion Paroxetine combined with mirtazapine can effectively improve cognitive function and depression in patients with PSD.
stroke depressionParoxetineMirtazapineCognitive functionDegree of depression
万方数据
维普
