The Expression and Clinical Significance of Serum PC,hs-CRP and NT-proBNP in Different Coronary Artery Diseases of Coronary Heart Disease
Objective To investigate the expression and clinical significance of serum plasma protein C(PC),highly sensitive C-reactive protein(hs-CRP)and amino-terminal B-type brain natriuretic peptide(NT-proBNP)in coronary heart dis-ease(CHD)and coronary artery disease.Methods 80 cases of CHD patients and 80 cases of healthy people who underwent physical examination were selected as observation group and control group.According to clinical classification,CHD was di-vided into stable angina pectoris group(n=24),unstable angina pectoris group(n=31)and myocardial infarction group(n=25).Serum levels of PC,hs-CRP and NT-proBNP were detected in all patients.Coronary angiography was carried out in the ob servation group,and the patients were divided into single-branch lesion group(n=22),double-branch lesion group(n=34)and multi-branch lesion group(n=24)according to the number of coronary lesions.The levels of serum PC,hs-CRP and NT-proBNP in control group and observation group,different clinical types(stable angina pectoris group,unstable angina pectoris group,myocardial infarction group)and different coronary lesions(single-branch disease group,double-branch disease group,multi-branch disease group)were compared.A risk assessment model was established,and the diagnostic efficacy of serum PC,hs-CRP and NT-proBNP in detecting myocardial infarction was evaluated by receiver operating characteristic curve(ROC).Results Compared with the control group,the level of serum PC in the observation group was lower,the level of hs-CRP and NT-proBNP was higher(P＜0.05).Compared with unstable angina group and myocardial infarction group,the level of serum PC in stable angina group was higher,and the level of hs-CRP and NT-proBNP was lower(P＜0.05).The level of serum PC in multi-branch disease group was significantly lower than that in single-branch disease group and double-branch disease group,and the level of hs-CRP and NT-proBNP in multi-branch disease group was higher(P＜0.05).According to ROC curve analysis,the combined detection of serum PC,hs-CRP and NT-proBNP in the established risk assessment model had the highest AUC value,which was 0.958,and the sensitivity and specificity were 96.00%and 84.00%.Conclusion The more severe the coronary lesions in CHD patients,the lower the serum level of PC,hs-CRP,NT-proBNP levels.The serum levels of PC,hs-CRP and NT-proBNP have certain clinical value in the evaluation of different degrees of coronary lesions of CHD.The combined detection of serum PC,hs-CRP and NT-proBNP has high diagnostic efficacy in the diagnosis of coronary heart disease myocardial infarction.
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