摘要
目的 探讨双水平气道正压通气(BiPAP)联合甲强龙治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者效果;方法 选取 72 例AECOPD并呼吸衰竭患者分为两组,对照组给予BiPAP治疗,观察组联合甲强龙治疗,比较临床疗效,呼吸功能、肺功能、血气水平、炎症因子水平;结果 观察组疗效总有效率显著高于对照组(P<0.05),治疗前两组患者RR、HR、MAP、PaO2、PaCO2、SaO2、FEV1、FVC、FEV1/FVC、PCT、CRP指标水平差异无统计学意义(P>0.05),治疗后两组患者RR、HR、MAP、PaO2、PaCO2、SaO2、FEV1、FVC、FEV1/FVC、PCT、CRP指标水平均显著改善,且治疗后观察组呼吸功能、肺功能、血气水平、炎症因子水平改善更显著(P<0.05);结论 双水平气道正压通气联合甲强龙治疗AECOPD并呼吸衰竭患者可显著提高临床疗效,抑制气道和肺部炎症水平,改善患者肺功能,加速患者康复,值得推广.
Abstract
Objective To investigate the effect of BiPAP combined with methylprednone in the treatment of acute exac-erbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods 72 patients with AECOPD combined with respiratory failure admitted were divided into 2 groups.The control group was given BiPAP therapy,and the observation group was combined with methylprednone therapy.The clinical efficacy,respiratory function,lung function,blood gas level and inflammatory factor level were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05),but there were no significant differences in the levels of RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP between the two groups before treatment(P>0.05).After treatment,the lev-els of RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP in 2 groups were significantly improved.After treatment,RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP in observation group were significantly im-proved(P<0.05).Conclusion Bilevel positive airway pressure ventilation combined with methylprednone in the treatment of AECOPD patients with respiratory failure can significantly improve clinical efficacy,inhibit airway and lung inflammation lev-els,improve lung function,and accelerate the recovery of patients,which is worthy of promotion.
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