Effect of Bilevel Positive Airway Pressure Ventilation Combined with Methylprednisolone in The Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure
Objective To investigate the effect of BiPAP combined with methylprednone in the treatment of acute exac-erbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods 72 patients with AECOPD combined with respiratory failure admitted were divided into 2 groups.The control group was given BiPAP therapy,and the observation group was combined with methylprednone therapy.The clinical efficacy,respiratory function,lung function,blood gas level and inflammatory factor level were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05),but there were no significant differences in the levels of RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP between the two groups before treatment(P>0.05).After treatment,the lev-els of RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP in 2 groups were significantly improved.After treatment,RR,HR,MAP,PaO2,PaCO2,SaO2,FEV1,FVC,FEV1/FVC,PCT and CRP in observation group were significantly im-proved(P<0.05).Conclusion Bilevel positive airway pressure ventilation combined with methylprednone in the treatment of AECOPD patients with respiratory failure can significantly improve clinical efficacy,inhibit airway and lung inflammation lev-els,improve lung function,and accelerate the recovery of patients,which is worthy of promotion.
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