Serum AFP β-Analysis of the Screening Value of hCG,uE3 Combined with miR-146a-5p Detection For Down's Syndrome in Mid Pregnancy
Objective To analyze alpha fetoprotein(AFP)β-Human ch orionic gonadotropin(β-HCG),free Estriol(uE3)and microRNA-146a-5p(miR-146a-5p)were used to screen Down's syndrome in the second trimester of pregnancy.Methods 53 pregnant women in the second trimester with positive results of Down's syndrome screening were divided into the observation group,and 64 healthy pregnant women in the second trimester who underwent physical examination at the same time were divided into the control group β-HCG,uE3,miR-146a-5p differences;Draw the receiver operating curve(ROC)and analyze the effectiveness of combined detection of AFP,β-hCG,uE3,and miR-146a-5p in screening for Down's syndrome.Results showed that the AFP and uE3 levels in the observation group were(20.53±2.81)μg/L and(1.46±0.34)ng/mL,respectively,low-er than those in the control group(46.79±4.57)μg/L and(3.49±0.50)ng/mL,The β-hCG was(6.77±1.54)μg/L,and the miR-146a-5p was(3.24±0.67),which was higher than the control group(3.15±0.63)μg/L and(1.25±0.31),with a statistical differ-ence(P<0.05);ROC results display:The area under the curve(AUC)of AFP,β-hCG,uE3,and miR-146a-5p combined detection for Down's syndrome was 0.907(95%CI:0.848-0.967),which was higher than the screened separately 0.740(95%CI:0.650-0.830),0.844(95%CI:0.767-0.921),0.822(95%CI:0.746-0.899),and 0.839(95%CI:0.754-0.923).Conclusion The combina-tion of AFP,β-hCG,uE3,and miR-146a-5p can effectively screen for Down's syndrome in mid pregnancy,and has high practical value.
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