Correlation between Serum CEA,CA125 and AFP the Illnesscondition of Chronic Hepatitis B
Objective To investigate the correlation between serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),and alpha fetoprotein(AFP)and the illnesscondition of chronic hepatitis B(CHB).Methods 78 cases of patients with CHB in our hospital were selected,and they were divided into a mild group(n=26),a moderate group(n=26),and a se-vere group(n=26)based on the severity degree of the irillness condition.In addition,26 healthy individuals in the same period were selected as the control group.All personnel were tested for serum CEA,CA125,and AFP levels,the patients'liver and kidney functions were recorded,and the scores of Model for End Stage Liver Disease(MELD)were analyzed.The positive de-tection rates of serum CEA,CA125,and AFP were analyzed,and the levels of serum CEA,CA125,AFP,and as well as MELD scores among the groups were compared to analyze the correlation.Results There were no significant differences in the detectable rate of CEA positive 3.85%(1/26)and detectable rate of CA125positive7.69%(2/26)in the severe group com-pared with 3.85%(1/26)and 7.69%(2/26)in the moderate group and 3.85%(1/26)and 3.85%(1/26)in the mild group(P>0.05).The detectable rate of AFP positivein severe group was 50.00%(13/26),which was higher than 26.92%(7/26)in the moderate group and 19.23%(5/26)in the mild group(P<0.05);There were no significant differences in serum CEA and CA125 levels among the severegroup,the moderategroup,the mildgroup,and the control group(P>0.05);Compared with the control group,the AFP levels and MELD scores in the severegroup,the moderategroup,and the mild group were higher(P<0.05);Pearson analy-sis showed that serum AFP level(r=0.658,r=0.671)was positively correlated with MELD scores and severity degree of illness-conditionof chronic hepatitis B(P<0.05).Conclusion The serum AFP level will gradually increase with the aggravation of CHB patients,and there is a positive correlation between the AFP level and the severity of illnesscondition of CHB.
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