Effect of Dexmedetomidine Preemptive Analgesia on Serum Inflammatory Factors and Hemodynamics in Severely Burned Patients
Objective To analyze the application effect of dexmedetomidine preemptive analgesia in severe burn pa-tients.Methods 86 severe burn patients diagnosed and treated were selected and randomly divided into two groups,with 43 patients in each group.Observation group injected 10 minutes before anesthesia 1μg/kg dexmedetomidine,followed by 0.5 μg Pump at a rate of 1g/(kg·h),discontinue medication 30 minutes before surgery,and inject the same amount of physiological saline into the control group in the same manner.Compare the sedative and analgesic effects,serum inflammatory factor lev-els,and hemodynamics between the two groups.Results The analgesic onset time of the observation group was(2.06±0.41)minutes,shorter than the control group's(4.89±0.95)minutes,the analgesic duration was(123.48±10.67)minutes,and longer than the control group's(95.31±8.46)minutes,with a statistical difference(P<0.05);Before anesthesia(T0),two groups of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)、There was no statistically significant difference in levels of interleukin-6(IL-6),heart rate(HR),and mean arterial pressure(MAP)(P>0.05);30 minutes after the start of surgery(T1)and at the end of surgery(T2),the observation group showed CRP and TNF-α、IL-6,HR,and MAP were lower than the control group,with statistical differences(P<0.05).Conclusion Dexmetomidine can exert preemptive analgesic effects in severe burn patients,re-duce inflammatory reactions,stabilize patient hemodynamics,and has high clinical application value.It can be vigorously pro-moted and applied.
Severe burnsDexmetomidineAdvanced analgesiaInflammatory factorsHemodynamicsmean arterial pres-sure
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