T2DM Comparison of the Hypoglycemic Effect of Daggliptin and Liggliptin in Obese T2DM Patients with Poor Insulin Control
Objective To compare the hypoglycemic effect of daggliptin and liggliptin in obese T2DM patients with poor insulin control.Methods A total of 74 patients diagnosed with obese T2DM were selected as the study subjects.They were randomly divided into dagliazine group and lipliptin group,with 37 cases in each group.Both groups were treated with dagli-azine or lipliptin,respectively.Fasting blood glucose(FBG),postprandial 2h blood glucose(2h PBG)and glycosylated hemoglobin(HbA1c)were compared between the two groups.Body mass index(BMI),waist circumference(WC)and body FAT percentage(FAT)were compared between the two groups.Results After intervention,the level of lipid metabolism in both groups de-creased compared with that before intervention.However,the FBG(8.31±0.71),2h PBG(9.13±1.63)and HbA1c(8.86±0.82)in Ligliptin group were significantly better than those in Dagliegine group(9.78±0.91),(10.37±1.94)and(8.11±0.45).Obesity in-dexes in both groups were improved,but the decreasing trend in the lipliptin group was better than that in the dagliegine group,with statistical significance(P<0.05).Conclusion Daggliptin and liggliptin can effectively control blood sugar and re-duce the weight of obese T2DM patients with poor insulin control,which is worthy of clinical application.
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