脂质与糖尿病视网膜病变因果关系的孟德尔随机化分析
A Mendelian Randomization Analysis on the Causal Associations between Lipids and Diabetic Retinopathy
王鑫 1刘行海2
作者信息
- 1. 川北医学院影像学院,四川 南充 637000
- 2. 川北医学院基础医学与法医学院,四川 南充 637000
- 折叠
摘要
目的 探讨脂质与糖尿病视网膜病变的双向因果关系.方法 利用脂质和糖尿病视网膜病变(diabetic retinopa-thy,DR)全基因组关联研究汇总数据,通过逆方差加权法、MR-Egger 回归法和加权中位数法进行两样本双向孟德尔随机化分析,并采用Cochran's Q检验评估结果的异质性、MR-Egger 回归截距项检验水平多效性.结果 逆方差加权法结果显示,磷脂酰乙醇胺(16:0_18:2)(OR=0.916,95%CI:0.864～0.971,P=0.003,PFDR=0.174),三酰甘油 50:2(OR=0.850,95%CI:0.760～0.952,P=0.005,PFDR=0.174)会降低DR发病风险.反向MR分析结果显示,DR与甘油二酯(16:0_18:2)(OR=1.064,95%CI:1.021～1.109,P=0.003,PFDR=0.194)、三酰甘油 50:1(OR=1.067,95%CI:1.026～1.109,P=0.001,PFDR=0.194)的增加有因果关联.多种孟德尔随机化方法的结果都基本一致,且敏感性分析结果证明上述结果具有一致性和可靠性.结论 磷脂酰乙醇胺(16:0_18:2),三酰甘油50:2与DR发病风险有负向因果关系,DR对甘油二酯(16:0_18:2)、三酰甘油50:1 有正向因果关系.
Abstract
Objective To investigate the bidirectional causal relationship between lipid and diabetic retinopathy(DR).Methods Data of genome-wide association study on lipid and DR were collected.The bidirectional Mendelian randomization(MR)of two samples was performed by inverse variance weighted method,MR-Egger regression method and weighted median method.Cochran's Q test was used to check the heterogeneity of the results and the MR-Egger regression method to evaluate of the results.Results The results of inverse variance weighted method showed that phosphatidylethanolamine(16:0_18:2)(OR=0.916,95%CI:0.864～0.971,P=0.003,PFDR=0.174)and triacylglycerol 50:2(OR=0.850,95%CI:0.760～0.952,P=0.005,PFDR=0.174)decreased the risk of DR.The results of reverse MR analysis showed that DR was causally associated with increased diglycerol(16:0_18:2)(OR=1.064,95%CI:1.021～1.109,P=0.003,PFDR=0.194)and triacylglycerol 50:1(OR=1.067,95%CI:1.026～1.109,P=0.001,PFDR=0.194).The results of various MR methods were basically consistent,and the results of sensitivity analysis showed that the above results were consistent and reliable.Conclusion Phosphatidylethanolamine(16:0_18:2)and triacylglycerol 50:2 have negative causal associations with the risk of DR,while DR has positive causal effects on diglycerol(16:0_18:2)and triacylglycerol 50:1.
关键词
脂质/糖尿病视网膜病变/孟德尔随机化/因果推断Key words
lipid/Diabetic retinopathy/Mendelian randomization/Causal inference引用本文复制引用
基金项目
南充市市校合作科研专项(22SXQT0128)
川北医学院大学生创新创业训练计划项目(XJ202310634335)
出版年
2024
国家科技期刊平台
NSTL
万方数据