Effect of Henagliflozin Proline Combined with Metformin on Obese Type 2 Diabetes
Objective To investigate the therapeutic effect of Henagliflozin Proline combined with metformin on obese type 2 diabetes.Methods A total of 98 obese patients with type 2 diabetes mellitus(T2DM)undergoing treatment at the hospital were systematically randomized into two groups:an observation group of 49 individuals and a control group of 49 individuals,with the allocation executed using a random number table method.The control group was treated with metformin+liraglutide,while the observation group was treated with metformin+liraglutide+Henagliflozin Proline.After 3 months of treatment,the fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin(HbA1c),time within target range of glucose(TIR),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),body fat percentage,liver fat attenuation index,N-terminal pro brain natriuretic peptide(NT proBNP),glomerular filtration rate(eGFR),and adverse reactions were compared between the two groups.Results After treatment,the fasting blood glucose levels of the observation group and the control group were(7.01±1.21)mmol/L and(7.53±1.13)mmol/L,respectively.The postprandial 2-hour blood glucose levels were(8.34±1.16)mmol/L and(8.92±1.31)mmol/L,respectively.HbA1c levels were(6.85±1.15)%and(7.41±1.09)%,TIRc levels were(85.03±6.18)%and(82.27±6.52)%,TC levels were(5.26±0.85)mmol/L and(5.79±0.83)mmol/L,TG levels were(1.81±0.32)mmol/L and(1.95±0.35)mmol/L,respectively,and LDL-C levels were(2.37±0.35)mmol/L,respectively.0.39)mmol/L and(2.61±0.54)mmol/L,body fat percentage were(32.31±6.07)mmol/L and(35.05±7.21)mmol/L,liver fat attenuation index were(282.51±29.04)kPa and(294.37±28.19)kPa,and NT proBNP were(316.42±38.19)pg/mL and(408.35±41.67)pg/mL,respectively,with statistically significant differences(P<0.05).After treatment,the eGFReGFR of the two groups were(98.37±5.19)min·1.73m2 and(97.61±5.83)min·1.73m2,respectively,with no statistically significant difference(P>0.05).After treatment,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Henagliflozin Proline combined with metformin in the treatment of obese T2DM can help reduce blood glucose levels,control blood glucose fluctuations,regulate blood lipid levels,improve cardiac function,and has good efficacy and safety.
Type 2 diabetesObesityMetforminHenagliflozin Proline
万方数据
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