室上性心动过速不良反应的挖掘与分析

Mining and Analysis of Adverse Reactions to Supraventricular Tachycardia

陈小琴 ¹陈雨心 ²林彩婷 ³骆静怡 ²李少滨 ⁴陈伟鸿⁴

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作者信息

1. 安溪县医院门诊药房,福建泉州 362400
2. 宁德师范学院医学院,福建宁德 352106
3. 安溪县医院呼吸内科,福建泉州 362400
4. 安溪县医院临床药学室,福建泉州 362400
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摘要

目的本研究基于美国食品药品管理局不良事件报告系统(FAERS)数据库,对引起室上性心动过速(Supraventricular tachycardia,SVT)的药物进行数据挖掘,为相关药物的临床应用提供参考.方法通过使用OpenVigil网站收集FAERS数据库中 2014 年第 1 季度至2023 年第 3 季度的不良事件报告,利用比例失衡法得出可能引发SVT的药物.结果经筛选后共获取2 683 份报告,有286种药物产生阳性信号.综合多方面报道总结最有可能引起SVT的药物有茶碱、文拉法辛、昂丹司琼、伏立康唑、异丙托溴铵、帕罗西汀、沙丁胺醇、紫杉醇、福莫特罗.结论在临床用药时应重点关注特殊人群,加强用药中、用药后的心脏功能监测,及时采取干预措施,确保用药安全.

Abstract

Objective Based on the US Food and Drug Administration Adverse Event Reporting System(FAERS)database,this study mined data on drugs causing Supraventricular tachycardia(SVT),in order to provide reference for clinical application of related drugs.Methods Adverse event reports from the FAERS database from Q1 2014 to Q3 2023 were collected using the OpenVigil website to identify drugs that could trigger SVT.Results A total of 2683 reports were obtained after screening,and 286 drugs produced positive signals.The drugs most likely to cause SVT were theophylline,Venlafaxine,Ondansetron,voriconazole,ipratropium bromide,paroxetine,salbutamol,paclitaxel and formoterol.Conclusion We should pay attention to the special population,strengthen the monitoring of cardiac function during and after medication,and take timely intervention measures to ensure the safety of medication.

关键词

室上性心动过速/药品不良反应/数据分析/信号挖掘

Key words

Supraventricular tachycardia/Adverse drug reactions/Data analysis/Signal mining

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出版年

2024

哈尔滨医药

哈尔滨市医学会

哈尔滨医药

影响因子：0.697

ISSN：1001-8131

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