Analysis of the Therapeutic Effect of Patients with Chronic Obstructive Pulmonary Disease Treated with Methylprednisolone Combined with Ipratropium Bromide Nebulization Inhalation
Objective To analyze the effect of atomizing inhalation of methylprednisolone combined with ipratropium bromide on patients with chronic obstructive pulmonary disease(COPD).Methods A total of 98 COPD patients were selected and divided into a control group and a combined group according to different treatment plans.Among them,48 cases who were given ipratropium bromide nebulization inhalation were the control group,and 50 cases who were given methylprednisolone combined with ipratropium bromide nebulization inhalation were the combined group.The clinical efficacy and adverse reaction rate of the two groups were compared,as well as the levels of lung function[maximum voluntary ventilation(MVV),forced expiratory volume in one second(FEV1),ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC),percentage of forced expiratory volume in one second to predicted value(FEV1%)],blood gas[partial pressure of carbon dioxide(PaCO2),partial pressure of arterial oxygen(PaO2)],and related serum factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-9,interleukin(IL)-6]before and after treatment.Results The total clinical effective rate of the combined group was 90.00%,which was higher than that of the control group(72.92%)(P<0.05).After treatment,the MVV,FEV1,FEV1/FVC,and FEV1%levels in the combined group were higher than those in the control group(P<0.05).After treatment,the PaCO2 level in the combined group was lower than that in the control group,while the PaO2 level was higher than that in the control group(P<0.05).The decrease in the levels of hs-CRP,TNF-α,MMP-9,and IL-6 in the combined group after treatment was greater than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined use of methylprednisolone and ipratropium bromide for nebulized inhalation in the treatment of COPD has significant therapeutic effects,improving lung function,regulating blood gas levels,inhibiting inflammatory reactions in the body,and demonstrating certain safety.
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