Study on the Efficacy of Methotrexate Combined with Other Immunosuppressants in Refractory Rheumatoid Arthritis
Objective This study evaluates the efficacy of methotrexate(MTX)combined with other immunosuppressants in patients with refractory rheumatoid arthritis(RA).Methods The study included 100 patients with refractory RA who were ineffective with MTX monotherapy.They were randomly divided into two groups:the MTX combined with other immunosuppressants group and the MTX monotherapy group.Evaluation indicators included morning stiffness duration,tender joint count,swollen joint count,overall patient and physician assessment(VAS score),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),joint X-ray score,and health assessment questionnaire(HAQ)score.Results The MTX combination therapy group showed significant improvement in morning stiffness duration,tender joint count,swollen joint count,and levels of CRP and ESR compared to the monotherapy group.Joint X-ray scores indicated a slower progression of joint damage in the combination therapy group(P<0.05).Quality of life assessments revealed significant improvement in HAQ scores in the combination therapy group(P<0.01),with notable increases in all dimensions of the SF-36 score.Conclusion Methotrexate combined with other immunosuppressants shows significant therapeutic effects in patients with refractory RA.
万方数据
维普
