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促排卵药物的使用与孕期及围产期VTE发生的相关性研究

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目的 探究促排卵药物的使用与孕期、围产期VTE发生之间的相关性.方法 取 200 例孕期孕妇作为研究对象,以VTE发生情况作为分组依据,将 46 例存在VTE的孕妇纳为VTE组,将未出现VTE的 154 例孕妇纳为非VTE组.对比分析孕妇一般资料中相关因素对VTE发生情况的影响,对比两组孕妇的临床指标检验结果,分析促排卵药物的使用以及临床检验指标与VTE发生之间的相关性.结果 VTE组与非VTE组孕妇在年龄、胎数、BMI、高血压病史、糖尿病病史、血栓史与使用促排卵药物方面存在明显差异,并均为围产期VTE发生的危险因素(P<0.05).VTE组孕妇的TM、PIC、TAt检验结果同非VTE组相比更高(P<0.05).ROC曲线分析结果显示,使用促排卵药物、TM、PIC、TAT均与VTE发生具有正相关联系(P<0.05).结论 高龄、多胎、体质量偏高、高血压病史、糖尿病病史、血栓史以及使用促排卵药物的孕妇在孕期、围产期具有更高VTE发生风险,并且VTE孕妇在临床实验室指标上同非VTE孕妇存在明显差异,使用促排卵药物、实验室指标TM、PIC与TAT对于围产期VTE的发生均属于重要的独立危险因素.
Study on the correlation between the use of ovulation stimulating drugs and the occurrence of VTE during pregnancy and perinatal period
Objective To explore the correlation between the use of ovulation promoting drugs and the occurrence of VTE during pregnancy and perinatal period.Methods A total of 200 pregnant women were selected as research objects,and 46 pregnant women with VTE were classified as VTE group and 154 pregnant women without VTE were classified as non-VTE group according to the occurrence of VTE.The effects of relevant factors on the occurrence of VTE in the general data of pregnant women were compared,and the results of clinical indicators of pregnant women in the two groups were compared,and the use of ovulation promoting drugs and the correlation between clinical indicators and the occurrence of VTE were analyzed.Results There were significant differences between VTE group and non-VTE group in age,number of births,BMI,history of hypertension,history of diabetes,history of thrombosis and use of ovulation promoting drugs,and the risk factors of perinatal VTE were averaged(P<0.05).The results of TM,PIC and TAT in VTE group were higher than those in non-VTE group(P<0.05).ROC curve analysis showed that the use of ovulation stimulating drugs,TM,PIC and TAT were positively correlated with the occurrence of VTE(P<0.05).Conclusion Pregnant women with old age,multiple births,high body weight,history of hypertension,diabetes,history of thrombosis and use of ovulation promoting drugs have a higher risk of VTE during pregnancy and perinatal period,and there are significant differences in clinical laboratory indicators between pregnant women with VTE and pregnant women without VTE.Use of ovulation stimulating drugs,laboratory markers TM,PIC and TAT are important independent risk factors for the development of perinatal VTE.

ovulation stimulating drugsPerinatal VTEcorrelation

黄芳、朱秋萍、黄小燕

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佛山市妇幼保健院产科,广东 佛山 528000

促排卵药物 围产期VTE 相关性

2024

哈尔滨医药
哈尔滨市医学会

哈尔滨医药

影响因子:0.697
ISSN:1001-8131
年,卷(期):2024.44(6)