首页|基于"乙癸同源"理论探讨白癜风治疗的免疫机制

基于"乙癸同源"理论探讨白癜风治疗的免疫机制

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"乙癸同源"的实质与神经-内分泌-免疫网络密切相关。肝肾同居下焦,卫气防御外邪、温煦全身、开阖腠理,与保护机体免受异物侵袭并维持生理平衡和内环境稳态的现代免疫异曲同工。白癜风根于机体异常的免疫细胞与免疫环境(肝肾不足、精亏血虚),受氧化应激(外邪和情志不调)诱发启动了一系列的免疫反应,在皮肤形成了失衡的组织微环境(气血不和),导致黑素细胞的凋亡,呈现出异常的皮肤白斑。为"治病求本",临证应从"肝肾同治"入手,发挥中医药多靶点、多通路的优势,通过神经-内分泌-免疫网络调控免疫细胞与相关细胞因子,改善免疫微环境,从而达到"阴平阳秘"的免疫平衡状态,使黑素细胞恢复、再生,逆转疾病。
Immune Mechanism in Treating Vitiligo with Liver and Kidney Simultaneous Treatment Method Based on"Homology of Yi and Gui"
"Homology of Yi(Liver)and Gui(Kidney)"is closely related to the neuro-endocrine-immune network.Liver and Kid-ney reside in the Lower Jiao,Wei Qi defenses against external evil factors,warms the whole body,open and close the sweating pore,which is just like the case that modern immune function in balancing internal physiological environment and maintaining the inner ho-meostasis by protecting the body from foreign invasion.Vitiligo is rooted in the body's abnormal immune cells and immune environment(Liver and Kidney insufficiency,Essence deficiency and blood deficiency),by oxidative stress(external evil factors and emotional dis-orders)induced a series of immune reactions,the formation of an imbalance in the skin micro-environment of the tissue(Qi and blood disharmony),leading to the apoptosis of melanocytes,presenting abnormal white spots on skin.In order to"seek the root cause of the disease",the clinical evidence should start from"the simultaneous treatment of Liver and Kidney",give full play to the advantages of Chinese medicine of multi-targets,multi-pathways,through the neural-endocrine-immune network to regulate the immune cells and related cytokines,to improve the immune microenvironment,so as to achieve The immune balance of"Yin and Yang balance"is a-chieved,so that melanocytes can be restored and regenerated,and the disease can be cured.

vitiligoimmune mechanism"homology of Yi(Liver)and Gui(Kidney)"Liver-Kidney simultaneous treatment

孙源、杨泽雨、沈洋、李建红

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北京中医药大学第一临床医学院,北京 100700

北京中医药大学东直门医院,北京 100700

白癜风 免疫机制 "乙癸同源" 肝肾同治

2025

中医学报
河南中医药大学,中华中医药学会

中医学报

影响因子:1.264
ISSN:1674-8999
年,卷(期):2025.40(1)