Medication Rule of TCM Patent Compound Formula in Treatment of Pulmonary Fibrosis Based on Data Mining
Objective:To analyze the medication pattern of Chinese medicine patent compound for the treatment of pulmonary fibrosis.Methods:Using"pulmonary fibrosis"and"interstitial fibrosis"as search terms,we searched the website of China Patent Publication An-nouncement of the State Intellectual Property Office(SIPO)for relevant Chinese medicine formulas,and carried out data screening,data entry,data sorting,and data statistical analysis;data mining methods included network analysis,association rule analysis,and so on.The data mining methods include network analysis,association rule analysis,etc.Results:A total of 136 patented Chinese medicine formulas for the treatment of pulmonary fibrosis were included,with the application of 378 Chinese medicines,of which the top four Chinese med-icines were Gancao(Licorice),Huangqi(Astragalus),Danshen(Salvia miltiorrhiza)and Danggui(Angelica)in the order of applica-tion frequency.The overall medicinal properties were mostly cold,warm,and flat;The medicinal flavors were mostly sweet,bitter,and pungent;The meridian tropism of the medicines were mostly Lung,Liver and Spleen meridians.The results of network analysis showed that the combinations of Chinese medicines with higher links were Gancao-Huangqi(Licorice-Astragalus),Huangqi-Danggui(As-tragalus-Angelica),Huangqi-Danshen(Astragalus-Salvia miltiorrhiza),and Gancao-Danggui(Licorice-Angelica);The results of association rule analysis showed that,combining the support and confidence levels,the related medicines with higher associations in-cluded:Huangqi-Danggui(Astragalus-Angelica),Gancao-Huangqi(Licorice-Scutellariae Radix),Gancao-Banxia(Licorice-Pinellia ternata)and Huangqi-Danshen(Astragalus-Salvia miltiorrhiza),and so on.Conclusion:The core drugs in the patented com-pound formula of traditional Chinese medicine for the treatment of pulmonary fibrosis are Gancao(Licorice),Huangqi(Astragalus),Danshen(Salvia miltiorrhiza)and Danggui(Angelica),mainly benefiting Qi and activating blood when they are used in combination with other medicines that can strengthen the Spleen,relieve cough,resolve Phlegm and asthma,clear Heat and nourish Yin based on the clinical practice;Combined with the law of medication,it is believed that the pathogenesis of pulmonary fibrosis in Chinese medicine mainly consisted of the deficiency in root and excess in syndrome,namely,the deficiency in Qi or Yin in the Lung and Spleen,and the excess in symptom includes blood stasis blocking,Phlegm and Turbidity as well as Heat and Toxin.
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