TCM Microenvironmental Regulation Mechanism of Coronary Artery Critical Lesion Plaques from Perspective of"Phlegm-Stasis and Heat-Toxin"
Critical coronary lesions are a special stage in the development of coronary atherosclerotic heart disease,in which multiple bi-ological components within the plaque microenvironment interact with each other to form a complex ecosystem.The evolution of"Phlegm-Stasis and Heat-toxin"in critical lesions of coronary artery corresponds to the modern pathological mechanisms of inflammatory reac-tion,endothelial damage,neovascularization and lipid metabolism.Therefore,the clinical treatment should adopt the method of"elimina-ting,clearing and dredging"to regulate the plaque microenvironment of critical lesions of coronary artery,i.e.:eliminating Phlegm and stasis to improve endothelial damage and lipid deposition;clearing Heat and toxin to suppress the inflammatory reaction;dredging merid-ians and collaterals to suppress the vascularization in the plaque.In this way,it can play the role of anti-inflammatory,improve the quality of blood vessels in plaque.In this way,anti-inflammation,improvement of endothelial and lipid metabolism,and inhibition of plaque neovascularization can be realized,and the whole-cycle dynamic intervention model of"Phlegm-stasis and Heat-Toxin"for critical coronary lesions can be constructed together.
critical lesions of coronary artery"Phlegm-stasis and Heat-toxin"atherosclerosisplaque microenvironmentneovascu-larization
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