首页|基于脑-肠轴理论探讨枳实-白术药对治疗功能性便秘的作用机制

基于脑-肠轴理论探讨枳实-白术药对治疗功能性便秘的作用机制

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功能性便秘(functional constipation,FC)发生的作用机制与脑-肠轴系统的传导异常密切相关,而脑肠肽也为脑肠的生理和病理相关提供了物质基础,脑与肠之间密切的联系为FC的诊治提供了重要理论依据.中药枳实、白术均具有消食除痞的功效,在临床中枳实-白术亦是治疗FC的经典药对,二者一消一补,共行健脾益气、通便行滞之功.现代研究发现枳实和白术合用不仅可调节某些脑肠肽的水平,促进胃排空,增强小肠推进,还可发挥抑菌作用,使肠道菌群处于更有益的状态.此外,该药对还能改善患者的心理焦虑状况,有助于改善患者症状.
Action Mechanism of Paired Medicine Zhishi-Baizhu(Fructus Aurantii-Atractylodes)in Treating Functional Constipation from Brain-Intestinal Axis Theory
The mechanism of functional constipation(FC)is closely related to the conduction abnormality of the brain-intestinal axis system,and brain-intestinal peptide also provides a material basis for the physiology and pathology of the brain and intestine,and the close connection between the brain and the intestine provides an important theoretical basis for the diagnosis and treatment of FC.The Chinese paired medicine Zhishi-Baizhu(Fructus Aurantii-Atractylodes),which is a classic paired medicine in treatment of FC in clinic,have the efficacy of eliminating food and removing lumps,with eliminating with one and supplementing with the other.It can strengthen the Spleen and benefit the Qi,and improve the bowel movements and relieve Qi stagnation.Modern research has found that the combination of Zhishi and Baizhu can not only regulate the level of certain brain peptides,promote gastric emptying and enhance the propulsion of small intestines,but also play an antibacterial role,so that intestinal flora is in a more beneficial state.In addition,the pair also improves patients'psychological anxiety and helps to relieve their symptoms.

functional constipationbrain-intestinal axisZhishi(Fructus Aurantii)Baizhu(Atractylodes)brain-intestinal pep-tidecouplet medicinals

李天天、杨会举、刘佃温、杨新玉、梁薇、王蔷、商云飞

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河南中医药大学,河南郑州 450046

河南中医药大学第三附属医院,河南郑州 450008

功能性便秘 脑-肠轴 枳实 白术 脑肠肽 药对

2025

中医学报
河南中医药大学,中华中医药学会

中医学报

影响因子:1.264
ISSN:1674-8999
年,卷(期):2025.40(1)