The mechanism of functional constipation(FC)is closely related to the conduction abnormality of the brain-intestinal axis system,and brain-intestinal peptide also provides a material basis for the physiology and pathology of the brain and intestine,and the close connection between the brain and the intestine provides an important theoretical basis for the diagnosis and treatment of FC.The Chinese paired medicine Zhishi-Baizhu(Fructus Aurantii-Atractylodes),which is a classic paired medicine in treatment of FC in clinic,have the efficacy of eliminating food and removing lumps,with eliminating with one and supplementing with the other.It can strengthen the Spleen and benefit the Qi,and improve the bowel movements and relieve Qi stagnation.Modern research has found that the combination of Zhishi and Baizhu can not only regulate the level of certain brain peptides,promote gastric emptying and enhance the propulsion of small intestines,but also play an antibacterial role,so that intestinal flora is in a more beneficial state.In addition,the pair also improves patients'psychological anxiety and helps to relieve their symptoms.
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