首页|基于"荣卫稽留"理论探讨中性粒细胞胞外诱捕网对慢性子宫内膜炎的影响

基于"荣卫稽留"理论探讨中性粒细胞胞外诱捕网对慢性子宫内膜炎的影响

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慢性子宫内膜炎(chronic endometritis,CE)为慢性炎症迁延不愈所致,其发病的主要原因为微生物感染。CE的发病与中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)的异常堆积密切相关。NETs可以对微生物进行限制及杀伤,参与机体内血栓形成和免疫调节,当NETs的形成与消除达到平衡时对机体是有益的,然而慢性感染或自身免疫紊乱等病理过程可打破这一平衡,直接引起组织损伤和炎性反应增强。中医认为,此为久病卫气虚损,卫外不固所致。邪气留滞,卫气受阻,营血不行,病久卫气愈虚,行血无力,营血瘀阻,气不得滋,终致"荣卫稽留",从而诱发CE。CE的核心病机在于"荣卫稽留-NETs异常堆积-CE关联"。。
Discussion on Role of Neutrophil Extracellular Trapping Network in Chronic Endometritis Based on Theory of"Rong Wei Ji Liu"
Chronic endometritis(CE)is the result of chronic inflammation,the main cause of which is microbial infection.The patho-genesis of CE is closely related to the abnormal accumulation of neutrophil extracellular traps(NETs),which can restrict and kill mi-croorganisms and participate in thrombosis and immunoregulation.NETs can restrict and kill microorganisms and participate in thrombo-sis and immune regulation in the body.When the formation and elimination of NETs reach a balance,it is beneficial to the body;however,pathological processes such as chronic infections or autoimmune disorders can disrupt this balance,directly causing tissue damage and increase inflammatory response.According to Chinese medicine,this is caused by the deficiency of Wei Qi in chronic diseases and the Wei Qi deficiency.The evil factor Qi stagnates,and Wei Qi get blocked and Ying blood movement is affected.Long-term illness would cause further deficiency of Wei Qi and Ying blood stasis would take place.Ying blood stagnation cannot tonify Qi and causes"Rong Wei Ji Liu"and then"Rong Wei Ji Liu-abnormal accumulation of NETs-CE correlation.

chronic endometritis"Rong Wei Ji Liu"neutrophil extracellular trapping networkstrawberry signmicropolypsmicro-thrombus

郭佳易、贺丰杰、李楠、刘娜

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延安市中医医院,陕西延安 716000

陕西中医药大学附属医院,陕西咸阳 712000

慢性子宫内膜炎 "荣卫稽留" 中性粒细胞胞外诱捕网 草莓征 微息肉 微血栓

2025

中医学报
河南中医药大学,中华中医药学会

中医学报

影响因子:1.264
ISSN:1674-8999
年,卷(期):2025.40(1)