抗肿瘤药物卡博替尼和替沃扎尼关键中间体4-羟基-6,7-二甲氧基喹啉合成工艺的研究
Study on the Synthesis of 4-hydroxy-6,7-dimethoxyquinoline,the Key Intermediates of Anti-tumor Drugs Cabozantinib and Tivozanib
李守湖 1闫国毅 1高恩 2丁晓 1高留洋 1王帆3
作者信息
- 1. 新乡学院药学院 河南 453000
- 2. 河南师范大学化学化工学院 河南 453000
- 3. 河南知唯生物医药有限公司 河南 453000
- 折叠
摘要
4-羟基-6,7-二甲氧基喹啉是新型靶向药物分子卡博替尼和替沃扎尼的共同关键中间体,其质量和成本的高低直接影响着原料药的生产成本和市场成品药的定价.总结了关键中间体 4-羟基-6,7-二甲氧基喹啉的合成工艺,并分析其优缺点,为卡博替尼、替沃扎尼原料药及其中间体的合成研究和工业化生产提供帮助.
Abstract
4-hydroxy-6,7-dimethoxyquinoline is a common key intermediate of new targeted drug molecules cabozantinib and tivotinib.Its quality and cost directly affect the production cost of active pharmaceutical ingredients and the pricing of finished drugs in the market.The synthesis process of the key intermediate 4-hydroxy-6,7-dimethoxyquinoline was summarized,and its advantages and disadvantages were analyzed,which provided help for the synthesis research and industrial production of cabozantinib,tivozanib API and its intermediates.
关键词
卡博替尼/替沃扎尼/4-羟基-6,7-二甲氧基喹啉/合成工艺Key words
cabozantinib/tivozanib/4-hydroxyl-6,7-dimethoxy/synthesis引用本文复制引用
出版年
2025
NETL
NSTL
万方数据